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Clinical JudgmentRead the pattern, not the story

ToxidromesNREMT cheat sheet

Recognizing a poisoning by its pattern rather than by what the patient or bystanders say was taken. Two of them are exact mirrors of one another, which is why they are examined together.

15 key facts Reviewed Oct 2026
The 1-minute sheetCinnaEMS

Mirrors

  • Anticholinergic: DRY, hot, dilated, fast, retaining
  • Cholinergic: WET everywhere, small pupils, slow

Kills By

  • Cholinergic → secretions → suction + ventilate
  • Opioid → respirations → ventilate BEFORE naloxone

The Split

  • Sympathomimetic sweats
  • Anticholinergic does not
Key takeaway

Anticholinergic: dry, flushed, hot, dilated pupils, tachycardic, retaining urine.

Key points to remember

  • Anticholinergic: dry, flushed, hot, dilated pupils, tachycardic, retaining urine.
  • Cholinergic: wet everywhere, constricted pupils, bradycardic, fasciculating.
  • Opioid: depressed respirations with pinpoint pupils — ventilate before the antidote.
  • Sympathomimetic: agitated, dilated, tachycardic, but DIAPHORETIC — the sweat splits it from anticholinergic.

Field priorities

  1. Cholinergic kills through secretions — airway and suction first.
  2. Opioid death is respiratory — ventilation precedes naloxone.

Coaching the patient

  • Sweat is the single finding that separates sympathomimetic from anticholinergic.

Red flags: act now

  • Fasciculations with copious secretions
  • Hot dry skin with agitation and retention

Toxidromes: FAQs

What are the priority actions for Toxidromes in the field?

Cholinergic kills through secretions — airway and suction first. Opioid death is respiratory — ventilation precedes naloxone.

What findings in Toxidromes change your plan or your transport decision?

Fasciculations with copious secretions. Hot dry skin with agitation and retention.

What do I need to know about Toxidromes for the NREMT?

Anticholinergic: dry, flushed, hot, dilated pupils, tachycardic, retaining urine. Cholinergic: wet everywhere, constricted pupils, bradycardic, fasciculating. Opioid: depressed respirations with pinpoint pupils — ventilate before the antidote. Sympathomimetic: agitated, dilated, tachycardic, but DIAPHORETIC — the sweat splits it from anticholinergic.

What should the crew communicate or document for Toxidromes?

Sweat is the single finding that separates sympathomimetic from anticholinergic.

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